Lillie, the daughter of Ed and Marianne Matthews, was an AP Scholar with Distinction and member of the National Honor Society at Handley. She was a member of the Interact Club, a community service organization, for four years.

Lillie ran on the cross country, indoor track and outdoor track teams. She was on the 2012 AA Outdoor Track State Championship team and a part of the state record setting 4x100 meter relay team. She received the Maddox-Perry Athletics and Academic Excellence Award and the Bill Johnson Unsung Hero Award in 2011-2012.

Lillie graduated from the University of Virginia in 2016 with a Bachelor of Science degree in biology. She was a volunteer at Students for Stop Hunger Now and the Madison House Medical Services at UVA Hospital while an undergraduate.

She was a Princess in the Court of Queen Shenandoah LXXXVIII during the 2015 Shenandoah Apple Blossom Festival.

Lille worked as a physical therapy technician at Spectrum Physical Therapy until 2018 when she entered medical school at Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia. She scored in the top 10% of applicants nationwide taking the Medical College Admissions Test. She became a member of the Hobart Amory Hare Medical Honor Society. Her research projects were in gastroenterology, telemedicine and cystic fibrosis. 

Lillie is currently in her second year of Internal Medicine Residency at Wake Forest Baptist Medical Center. She lives in Winston-Salem, North Carolina with her partner and 3 cats.

When told her “Handley Notables” article would be published with that of her high school coach, Mike McKiernan, Lillie commented: “I think it's adorable that I happen to be running in the Winchester Star with Coach Mckiernan. He was an incredible teacher, coach and mentor to me.”